Targeted Nanotechnology: Delivering Small but Deadly Punches

Delivering Three Punches to Knockout Intracellular Bacteria

Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.

Targeted Nanotechnology in Glioblastoma Multiforme

Gliomas, and in particular glioblastoma multiforme, are aggressive brain tumors characterized by a poor prognosis and high rates of recurrence. Current treatment strategies are based on open surgery, chemotherapy (temozolomide) and radiotherapy. However, none of these treatments, alone or in combination, are considered effective in managing this devastating disease, resulting in a median surviv...

Nanotechnology: thinking small.

Nanotechnology--building devices on the atomic scale--may unleash some big scientific advances early in the new millennium. Last January in Arlington, Virginia, nearly 100 representatives from academia, industry, and government laid out the general goals for the next decade of nanotechnology research by U.S. government agencies. Some predict that the potentially rich opportunities in this field...

Anthrax in USA--attacks "deadly but treatable".

Nanotechnology for molecular imaging and targeted therapy.

The recent emergence of “molecular imaging” as an integrated discipline in academic medical centers has set the stage for an evolutionary leap in diagnostic imaging and therapy.1 Molecular imaging is not a substitute for the traditional process of image formation and interpretation, but is intended to improve diagnostic accuracy and sensitivity by providing an in vivo analog of immunocytochemis...